Contact us
The world's leader in noninvasive Peyronie's Disease treatment

H100® Peyronie’s Disease Treatment Breakthrough

A non-surgical option shown in studies to help reduce curvature, pain, and scar tissue
Telemedicine Options

Key Facts About H100® Treatment for Peyronie’s Disease

  • H100® is a non-surgical, topical gel applied to the penis
  • Clinical trials showed up to 40% reduction in curvature after 6 months of use1
  • Works best in acute (early) stages of Peyronie’s Disease, but may help in all stages
  • Contains powerful ingredients delivered directly into scar tissue
  • No injections or surgery needed

How H100® Works to Help Peyronie’s Disease

H100® is a gel you apply directly to the penis. It’s designed to penetrate deeply into scar tissue that causes the bend or pain of Peyronie’s Disease. Over time, it may help soften scar tissue and reduce curvature. H100® contains a mix of proven ingredients, including:

Emu Oil2

Helps medicine absorb through the skin

Nicardipine5

A medicine shown in studies to help Peyronie’s tissue

Superoxide Dismutase (SOD)6

Helps reduce inflammation and scar tissue

Many men saw significant results in a clinical trial, with less pain and straighter erections after a few months of use1.

Dr. Twidwell Explains H100® Research, Ingredients & Who It’s For

Additional Resources for H100® & Peyronie’s Disease

How to Apply H100® for Peyronie’s Disease — Dr. Twidwell Explains

Stretching Made Simple: Your How-To Guide

If you’re using H100® treatment for Peyronie’s disease, adding a simple stretching routine can help improve your results. Here’s how to do it:

  • Make sure your penis is completely soft (not erect)
  • Gently hold the tip of your penis with one hand and the base with the other
  • Slowly pull it outward, away from your body, until it’s stretched to its full length—but never to the point of pain
  • Hold the stretch for about 30 seconds, then relax
  • Repeat this stretch three times a day if possible

Stretching helps prevent new scar tissue from forming and supports the remodeling of existing plaques, making it an important part of treatment with H100®.

Benefits of Penile Stretching and Remodeling

  • May help reduce penile curvature over time
  • Supports the remodeling of scar tissue
  • Helps maintain or restore penis length and flexibility
  • Can improve comfort during erections
  • May enhance results of treatments like H100®

Important Safety Tips for Penile Stretching Exercises

  • Only stretch when the penis is completely flaccid
  • Never force a stretch that causes pain
  • Avoid overly vigorous pulling
  • If pain increases or symptoms worsen, stop and contact a doctor
  • Follow your medical provider’s guidance for stretching routines

Take the Next Step Toward PD Treatment

You don’t have to live with pain, curvature, or uncertainty. H100® offers a non-surgical option that may help reduce scar tissue and improve results. If you’re curious whether it’s right for you, we’re here to help you move forward with confidence and privacy.

Patient Resources
Prescriber Resources

Is H100® Right for Me?

Wondering if H100® might help you? Here’s what to know:

Best Results in Acute (Early) Stage Peyronie’s

H100® often works best during the acute (early) phase of Peyronie’s disease—usually the first 12 months after symptoms start. During this time, scar tissue is still forming, and treatments may have a greater impact.

Even if you’ve had Peyronie’s for a while, H100® may still help soften scar tissue and reduce curvature, though changes can take longer and results may vary.

Most men don’t experience side effects from H100®. A few have reported mild skin irritation or rash at the application site, which typically goes away on its own or with simple skin care.

H100® offers a topical, non-invasive approach for Peyronie’s disease—no needles or surgery required.

H100® is a gel you apply yourself, making it simple and private to use at home.

If you’re dealing with Peyronie’s disease and want a non-surgical option, H100® might be worth exploring. Every case is unique, so it’s important to discuss your specific situation with a specialist.

  1. J Twidwell, L Levine. Topical treatment for acute phase Peyronie’s disease utilizing a new gel, H-100: a randomized, prospective, placebo-controlled pilot study. International Journal of Impotence Research (2016) 28, 41–45; doi:10.1038/ijir.2015.22.
  2. Zemtsov A, Gaddis M, Montalvo-Lugo V. Moisturizing and Cosmetic Properties of Emu Oil: A Double Blind Study. Australas J Dermatol 1996; 37: 159–161.
  3. Qiu XW, Wang JH, Fang XW, Gong ZY, Li ZQ, Yi ZH. Anti-inflammatory activity and healing-promoting effects of topical application of emu oil on wound in scalded rats. [Article in Chinese]. Di Yi Jun Yi Da Xue Xue Bao 2005; 25: 407–410.
  4. Yoganathan S, Nicolosi R, Wilson T, Handelman G, Scollin P, Tao R et al. Antagonism of croton oil inflammation by topical emu oil in CD-1 mice. Lipids 2003; 38: 603–607.
  5. Soh J, Kawauchi A, Kanemitsu N, Naya Y, Ochial A, Naltoh Y et al. Nicardipine vs saline injection as treatment for Peyronie’s disease: a prospective, randomized, single-blind study. J Sex Med 2010; 7: 3743–3749.
  6. Riedl C, Sternig P, Galle G, Langmann F, Vcelar B, Vorauer K et al. Liposomal recombinant human superoxide dismutase for the treatment of Peyronie’s disease: a randomized placebo-controlled double-blind prospective clinical study. Eur Urol 2005; 48: 656–661.