To date, controlled trials have failed to show any reliable efficacy with oral therapies.
Verapamil has been tried as a topical gel, rubbed on the penis. There is little evidence to show that the drug reaches the diseased tissue.
Needle injections of verapamil or interferon into the penis require local anesthesia with administration, and treatment results have been inconsistent.
Injection of collagenase Xiaflex® was recently FDA approved. It requires up to eight needle injections. Drug cost and local side effects are potential issues.
Surgical repair with either plication or grafting procedures remains the most common treatment for men with significant, stable Peyronie’s disease.