Q:  When can I expect results?

A:  In our study most patients found some improvement in pain and plaque size after three months.1 This is the first step in fixing curvature.  Over time, further reduction and remodeling of plaque may take place. We recommend you use H100 for a minimum of six months along with recommended stretching activity.


Q:  How often should I apply H100?

A:  Use this medication exactly as instructed when your prescription arrives. This means applying H100 two times per day—once in the morning and then again in the evening. If you miss a dose, apply as soon as possible while allowing at least four hours in-between doses. Then continue as instructed.


Q:  Is there a specific application method for H100?

A:  Cover the entire penile shaft twice each day. Do not apply to head of penis. This will help ensure that equal amounts of medicine reach both the affected area and any unseen or undiscovered subdermal plaque.


Q:  What side effects might I expect?

A: The only known side effect or adverse reaction with H100 is a skin rash in the area of application for approximately ten-percent of patients. In such event, treatment should be stopped and after the rash subsides, patients may re-start treatment using H100 once rather than twice daily. You may increase application back to twice daily if rash does not recur or is mild with once daily use.
Over-the-counter hydrocortisone cream has been used to treat the rash.  If the rash is severe, resuming H100 treatment is not recommended. For any side effects you should contact your prescribing physician for treatment recommendations.

No compounded medication is reviewed by the FDA for safety and efficacy.

Q:  Can I have intercourse while treating PD with H100?

A:  Yes, however, to avoid itching or burning in your partner’s genital region, we recommend thoroughly washing your penis with mild soap and water prior to having sex.


Q:  Is age a factor for treatment with H100?

A:  No.  Any person experiencing the symptoms of PD may be treated with H100.


Q:  What if I’m not getting better after six months of treatment?

A:  People may react differently to any type of treatment. Work closely with your doctor to monitor your status. If no progress has been achieved after six months, other treatment options may be needed.


Q:  Is it safe to use H100 while taking other medications?

A:  There are no known medication restrictions with H100 use. Patients with a known allergy or reaction to nicardipine, superoxide dismutase or emu oil should NOT use this product.


Q:  Will my medical insurance cover H100 treatment?

A:  H100 is not currently covered by insurance.  Please check your insurance policy for specific coverage restrictions.

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1. J Twidwell, L Levine. Topical treatment for acute phase Peyronie’s disease utilizing a new gel, H-100: a randomized, prospective, placebo-controlled pilot study. International Journal of Impotence Research (2016) 28, 41–45; doi:10.1038/ijir.2015.22